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The Chemistry and Biology of Alkannin, Shikonin, and Related Naphthazarin Natural Products
Author(s) -
Papageorgiou Vassilios P.,
Assimopoulou Andrea.,
Couladouros Elias A.,
Hepworth David,
Nicolaou K. C.
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990201)38:3<270::aid-anie270>3.0.co;2-0
Subject(s) - naphthoquinone , chemistry , botany , biology , biochemical engineering , engineering
Wound healing properties of plant extracts that contain the naphthoquinone natural products alkannin ( 1 ) and shikonin ( 2 ) have been known for many centuries. More recently, the biological properties of 1 , 2 , and related derivatives have been demonstrated experimentally, and their production both by cell cultures and chemical synthesis has been studied extensively.