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New Diphosphite Ligands for Catalytic Asymmetric Hydrogenation: The Crucial Role of Conformationally Enantiomeric Diols
Author(s) -
Reetz Manfred T.,
Neugebauer Torsten
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990115)38:1/2<179::aid-anie179>3.0.co;2-z
Subject(s) - enantioselective synthesis , catalysis , enantiomer , asymmetric hydrogenation , chemistry , stereochemistry , combinatorial chemistry , organic chemistry
Efficient catalysis of asymmetric hydrogenations is possible with complexes of the type 1 which contain chiral diphosphites as ligands. Thus the Rh‐catalyzed hydrogenation of dimethyl itaconate with a catalyst containing 1,4:3,6‐dianhydro‐ D ‐mannite and conformationally enantiomeric diols is highly enantioselective.