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Discovery of Peptide–Zirconium Complexes That Mediate Phosphate Hydrolysis by Batch Screening of a Combinatorial Undecapeptide Library
Author(s) -
Berkessel Albrecht,
Hérault David A.
Publication year - 1999
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19990115)38:1/2<102::aid-anie102>3.0.co;2-h
Subject(s) - hydrolysis , combinatorial chemistry , phosphate , drug discovery , peptide , chemistry , substrate (aquarium) , peptide library , zirconium phosphate , biochemistry , biology , peptide sequence , ecology , gene
The combinatorial discovery of novel catalytic activity requires both library synthesis and suitable assays. By means of the test substrate 1 , undecapeptides such as A were identified within a library that accelerate phosphate hydrolysis in the presence of Zr 4+ .