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An Access to Glycoconjugate Libraries through Multicomponent Reactions
Author(s) -
Lockhoff Oswald
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981231)37:24<3436::aid-anie3436>3.0.co;2-z
Subject(s) - glycoconjugate , isocyanide , aldehyde , amine gas treating , combinatorial chemistry , chemistry , ugi reaction , component (thermodynamics) , organic chemistry , biochemistry , catalysis , physics , thermodynamics
Four‐component reactions : The Ugi reaction of four suitably functionalized carbohydrate derivatives (as a per‐O‐benzylated amine, an aldehyde, a carboxylic acid, and an isocyanide) allow the effective assembly of diverse compound libraries. The complex glycoconjugates formed can be deprotected (see the picture for an example), and the resulting glycomimetics are of high interest for screening purposes.