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A Surprising Solid‐Phase Effect: Development of a Recyclable “Traceless” Linker System for Reactions on Solid Support
Author(s) -
Bräse Stefan,
Enders Dieter,
Köbberling Johannes,
Avemaria Frank
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981231)37:24<3413::aid-anie3413>3.0.co;2-k
Subject(s) - solid phase synthesis , linker , phase (matter) , combinatorial chemistry , chemistry , solid surface , computer science , organic chemistry , biochemistry , chemical physics , programming language , peptide
Triazenes as “traceless” linkers for solid‐phase synthesis have been utilized for the attachment of arenes to a solid support and yield the corresponding products after various organometallic reactions (Heck reaction and asymmetric dihydroxylation, see the reaction scheme) and cycloadditions (Diels–Alder reaction). The triazene linker is distinguished by its accessibility, thermal robustness, and capability to undergo regeneration.