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A Convenient and General Method for Pd‐Catalyzed Suzuki Cross‐Couplings of Aryl Chlorides and Arylboronic Acids
Author(s) -
Littke Adam F.,
Fu Gregory C.
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981231)37:24<3387::aid-anie3387>3.0.co;2-p
Subject(s) - aryl , reagent , yield (engineering) , chemistry , combinatorial chemistry , reactivity (psychology) , catalysis , organic chemistry , materials science , medicine , alkyl , alternative medicine , pathology , metallurgy
From only commercially available reagents a wide array of Suzuki cross‐couplings of aryl chlorides with arylboronic acids can be effected in excellent yield [Eq. (a)]. This development provides a general solution to a long‐standing limitation of this extremely powerful process—the poor reactivity of inexpensive and readily accessible aryl chlorides. dba=dibenzylideneacetone.