Premium
Catalytic, Enantioselective Synthesis of α ‐Aminonitriles with a Novel Zirconium Catalyst
Author(s) -
Ishitani Haruro,
Komiyama Susumu,
Kobayashi Shū
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981204)37:22<3186::aid-anie3186>3.0.co;2-e
Subject(s) - enantioselective synthesis , strecker amino acid synthesis , aldimine , catalysis , zirconium , enantiomer , chemistry , organic chemistry , combinatorial chemistry , chirality (physics) , chiral symmetry , physics , quantum mechanics , quark , nambu–jona lasinio model
Strecker reactions of aldimines with Bu 3 SnCN in the presence of the novel chiral zirconium binuclear catalyst 1 provide α ‐aminonitriles in good yields and with high enantioselectivities. The reaction can be applied to a wide range of substrates. Since both enantiomers of the chiral sources are readily avaibable, both enantiomers of the α ‐aminonitriles are easily prepared according to this method. L= N ‐methylimidazole.