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Versatile Ligands for Palladium‐Catalyzed Asymmetric Allylic Alkylation
Author(s) -
Dierkes Peter,
Ramdeehul Shailesh,
Barloy Laurent,
De Cian Andre,
Fischer Jean,
Kamer Paul C. J.,
van Leeuwen Piet W. N. M,
Osborn John A.
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981204)37:22<3116::aid-anie3116>3.0.co;2-s
Subject(s) - tsuji–trost reaction , palladium , steric effects , catalysis , alkylation , allylic rearrangement , chemistry , medicinal chemistry , stereochemistry , organic chemistry
Palladium complexes of the chiral diphosphanes 1 and 2 which possess a rigid backbone and a large bite angle catalyze the alkylation of allyl compounds with both high enantioselectivities and reaction rates, particularly with less sterically demanding substrates. 1 : R=Me, X=S; 2 : R=H, X=C(CH 3 ) 2 .