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New Protecting Group Strategies for the Solid‐Phase Synthesis and Modification of Peptides, Oligonucleotides, and Oligosaccharides
Author(s) -
Seitz Oliver
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981204)37:22<3109::aid-anie3109>3.0.co;2-c
Subject(s) - protecting group , oligonucleotide , oligonucleotide synthesis , group (periodic table) , alkylation , chemistry , blocking (statistics) , peptide , solid phase synthesis , peptide synthesis , combinatorial chemistry , phase (matter) , stereochemistry , biochemistry , organic chemistry , computer science , catalysis , dna , computer network , alkyl
Blocking and activation can be achieved with protecting groups such as the ortho ‐nitrobenzenesulfonyl group (see picture). In solid‐phase peptide synthesis, this group can be used for temporary protection (path A) as well as the activation and selective N‐alkylation (path B) of an amino group.