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Enantioselective Allylic Substitution of Cyclic Substrates by Catalysis with Palladium Complexes of P,N‐Chelate Ligands with a Cymantrene Unit
Author(s) -
Kudis Steffen,
Helmchen Günter
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981116)37:21<3047::aid-anie3047>3.0.co;2-j
Subject(s) - palladium , allylic rearrangement , enantioselective synthesis , chemistry , chelation , catalysis , substitution (logic) , stereochemistry , substitution reaction , medicinal chemistry , combinatorial chemistry , organic chemistry , computer science , programming language
Mechanistic considerations made a decisive contribution to the development of new chiral P,N ligands L* containing tricarbonylcyclopentadienylmanganese (cymantrene). These ligands induce very high enantioselectivities (>99:1) in allylic substitutions of cyclic substrates 1 with formation of 2 (2‐Bp=2‐biphenylyl).