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Cooperative Hydrogen Bonding and Enzyme Catalysis
Author(s) -
Guo Hong,
Salahub Dennis R.
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981116)37:21<2985::aid-anie2985>3.0.co;2-8
Subject(s) - hydrogen bond , catalysis , peptide , chemistry , hydrogen , enzyme catalysis , ligand (biochemistry) , low barrier hydrogen bond , enzyme , computational chemistry , chemical physics , combinatorial chemistry , stereochemistry , biochemistry , organic chemistry , receptor , molecule
An important contribution to enzyme catalysis may be made by cooperative effects—which are induced by the interactions of a negatively charged ligand L with peptide hydrogen bond networks—through stabilization of charge formation along the reaction pathway. This has been found from density functional calculations on model systems for peptide hydrogen bond networks (an example is shown in the picture).