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Enantioselective Hydrogenation of Olefins with Iridium–Phosphanodihydrooxazole Catalysts
Author(s) -
Lightfoot Andrew,
Schnider Patrick,
Pfaltz Andreas
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981102)37:20<2897::aid-anie2897>3.0.co;2-8
Subject(s) - iridium , enantioselective synthesis , catalysis , chemistry , hexafluorophosphate , trifluoromethyl , aryl , reactivity (psychology) , asymmetric hydrogenation , organic chemistry , medicinal chemistry , boron , ionic liquid , alkyl , medicine , alternative medicine , pathology
High turnover numbers and up to 98% ee were obtained in the catalytic hydrogenation of unfunctionalized aryl‐substituted olefins with iridium–phosphanyldihydrooxazole complexes 1 (see reaction scheme). The anion of the complex—for example, hexafluorophosphate or tetrakis[3,5‐bis(trifluoromethyl)phenyl]borate (BARF − )—has a remarkable effect on the reactivity and longevity of the catalyst.