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Metalated 2‐Alkenylsulfoximides in Asymmetric Synthesis: Diastereoselective Preparation of Highly Substituted Pyrrolidine Derivatives
Author(s) -
Reggelin Michael,
Heinrich Timo
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981102)37:20<2883::aid-anie2883>3.0.co;2-y
Subject(s) - pyrrolidine , stereocenter , reagent , absolute configuration , substrate (aquarium) , chemistry , stereochemistry , enantioselective synthesis , combinatorial chemistry , organic chemistry , catalysis , biology , ecology
Thanks to a productive interaction between reagent and substrate control, 2‐alkenylsulfoximides 1 react to provide highly substituted pyrrolidine derivatives 2 enantiomerically pure and with defined absolute configuration at the newly formed stereogenic centers. Tol=tolyl, BOC= tert ‐butoxycarbonyl.