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Transmembrane Transport of Adenosine 5′‐Triphosphate Using a Lipophilic Cholesteryl Derivative
Author(s) -
Kreimeyer Annett,
André François,
Gouyette Catherine,
HuynhDinh Tam
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981102)37:20<2853::aid-anie2853>3.0.co;2-3
Subject(s) - adenosine triphosphate , atp hydrolysis , chemistry , nucleoside triphosphate , nucleoside , adenosine , derivative (finance) , hydrolysis , biophysics , liposome , nuclear magnetic resonance spectroscopy , membrane , biochemistry , transmembrane protein , stereochemistry , nucleotide , atpase , enzyme , biology , receptor , financial economics , economics , gene
The uptake of ATP in liposomes was achieved by using the lipophilic derivative cholesteryloxycarbonyl‐ATP ( 1 ). Its hydrolysis leading to the release of ATP inside the vesicules (see scheme) was observed with the help of a pH gradient and monitored by 31 P NMR spectroscopy. This is the first successful transfer of a nucleoside 5′‐triphosphate across a membrane.