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Strategies for the Dynamic Integration of Combinatorial Synthesis and Screening
Author(s) -
Ganesan Arasu
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981102)37:20<2828::aid-anie2828>3.0.co;2-g
Subject(s) - schematic , property (philosophy) , selection (genetic algorithm) , representation (politics) , computer science , combinatorial synthesis , theoretical computer science , combinatorial algorithms , biochemical engineering , combinatorial chemistry , mathematical optimization , chemistry , algorithm , mathematics , artificial intelligence , engineering , philosophy , epistemology , electronic engineering , politics , law , political science
Selection and amplification of only those components with the desired property–the integration of combinatorial chemistry and screening makes this possible. If the components of a combinatorial library are in a reversible equilibrium, the desired components can be selected and amplified by shifting the equilibrium of the mixture (see schematic representation).