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Direct NMR Spectroscopic Observation of a Lanthanide‐Coordinated Water Molecule whose Exchange Rate Is Dependent on the Conformation of the Complexes
Author(s) -
Aime Silvio,
Barge Alessandro,
Botta Mauro,
De Sousa Alvaro S.,
Parker David
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981016)37:19<2673::aid-anie2673>3.0.co;2-#
Subject(s) - lanthanide , molecule , chemistry , nuclear magnetic resonance spectroscopy , crystallography , stereochemistry , organic chemistry , ion
A large difference in the exchange rate of the coordinated water molecule is seen in solution for the diastereoisomers M and m of a europium( III ) complex with an octadentate, neutral macrocyclic ligand ( k ex ( M )< k ex ( m )). This finding is of high relevance to the design of more efficient contrast agents for magnetic resonance imaging.