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Highly Enantio‐ and Diastereoselective Synthesis of 2‐Substituted 1‐Bicyclo[3.1.0]hexanols
Author(s) -
Mizojiri Ryo,
Urabe Hirokazu,
Sato Fumie
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981016)37:19<2666::aid-anie2666>3.0.co;2-k
Subject(s) - bicyclic molecule , propene , optically active , alkyl , chemistry , organic synthesis , stereochemistry , organic chemistry , catalysis
Useful intermediates in organic synthesis , optically active bicyclic cyclopropanols were difficult to prepare by existing methods. They can now be readily synthesized with high enantio‐ and diastereoselectivity from Oppolzer's N ‐acylcamphorsultams and [Ti(O i Pr) 2 ( η 2 ‐propene)] [Eq. (a)]. R=alkyl, alkenyl, benzyl, alkoxyalkyl, alkylsiloxyalkyl.