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Spongistatins, Cynachyrolides, or Altohyrtins? Marine Macrolides in Cancer Therapy
Author(s) -
Pietruszka Jörg
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981016)37:19<2629::aid-anie2629>3.0.co;2-a
Subject(s) - cancer , medicine , oceanography , geology
Fascinating structures and stunning cytotoxicities characterize the altohyrtins A–C, the spongistatins 1–9, and cynachyrolide A. The first total syntheses reported by the groups from Evans and Kishi could unequivocally prove the structure of the extremely potent inhibitors of the tubulin polymerization.