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Use of Lewis Acids in Free Radical Reactions
Author(s) -
Renaud Philippe,
Gerster Michèle
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981016)37:19<2562::aid-anie2562>3.0.co;2-d
Subject(s) - radical , lewis acids and bases , chemistry , enantioselective synthesis , catalysis , combinatorial chemistry , radical disproportionation , photoredox catalysis , neglect , organic chemistry , disproportionation , psychology , photocatalysis , psychiatry
The neglect of free radicals over the past few years has been overcome, and they are no longer only considered as interesting reactive intermediates with limited synthetic potential. New opportunities are opened up by performing radical reactions in the presence of Lewis acids. Rate enhancement of radical addition to olefins as well as stereochemical control of such reactions can be achieved in a unique manner. Recent examples of enantioselective radical reactions and perspectives for applications in catalysis are discussed.