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Solid‐Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of ( S )‐Zearalenone
Author(s) -
Nicolaou K. C.,
Winssinger Nicolas,
Pastor Joaquin,
Murphy Fiona
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981002)37:18<2534::aid-anie2534>3.0.co;2-f
Subject(s) - stille reaction , phase (matter) , zearalenone , solid phase synthesis , coupling (piping) , combinatorial chemistry , chemistry , materials science , organic chemistry , biochemistry , polymer , food science , metallurgy , aflatoxin , peptide
No heteroatom required! In many solid‐phase syntheses, after the release from the polymer support a heteroatom (e.g. O, S, N) remains in the substrate as a residue of a linking protecting group. With polymer‐bound tin reagents cleavage and cyclization of the substrate with C–C bond formation (see picture) can now be achieved by intramolecular Stille coupling. S =substrate.