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Efficient Synthesis of a Novel Estrone‐ Talaromycin Hybrid Natural Product
Author(s) -
Tietze Lutz F.,
Schneider Gyula,
Wölfling János,
Nöbel Thomas,
Wulff Christian,
Schubert Ingrid,
Rübeling Angela
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19981002)37:18<2469::aid-anie2469>3.0.co;2-m
Subject(s) - estrone , natural product , natural (archaeology) , product (mathematics) , computer science , biochemical engineering , chemistry , engineering , mathematics , geology , organic chemistry , biochemistry , paleontology , geometry , hormone
Numerous pharmacologically interesting compounds are available by the synthesis of hybrid natural products. Thus, for instance, the estrone–talaromycin hybrid 2 , which is synthesized in a few steps from the estrone derivative 1 by a sequence in which a hetero‐Diels–Alder reaction is the key step, exhibits notable cytotoxic activity.