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Crystal Structures of Actinomycin D and Actinomycin Z 3
Author(s) -
Schäfer Martina,
Sheldrick George M.,
Bahner Isabel,
Lackner Helmut
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980918)37:17<2381::aid-anie2381>3.0.co;2-l
Subject(s) - dimer , crystallography , ab initio , crystal (programming language) , molecule , diffraction , resolution (logic) , unit (ring theory) , crystal structure , chemistry , materials science , physics , nuclear magnetic resonance , optics , quantum mechanics , mathematics , computer science , mathematics education , artificial intelligence , programming language
Abstract Untwinned single crystals of the actinomycins D and Z 3 that diffracted to atomic resolution could be obtained for the first time. Low‐temperature data collection and a new ab initio method for solving the structures led to precise crystal structures which showed, for example, that the unit cell of actinomycin D contains three molecules, two of which are present in the form of a hydrogen‐bridged dimer related by a pseudo‐twofold axis (see picture).