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Oligomers with Intercalating Cytosine–Cytosine + Base Pairs and Peptide Backbone: DNA i‐Motif Analogues
Author(s) -
Diederichsen Ulf
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980904)37:16<2273::aid-anie2273>3.0.co;2-p
Subject(s) - cytosine , phosphodiester bond , dna , nucleobase , chemistry , nucleic acid , motif (music) , base pair , peptide , intercalation (chemistry) , stereochemistry , structural motif , biochemistry , rna , gene , physics , acoustics , inorganic chemistry
Alanyl peptide nucleic acids organize in a similar manner to the DNA structure motif by stabilizing two cytosine–cytosine + pairing double strands by intercalation (i‐motif). These analogues demonstrate that a tetrameric arrangement of nucleobases is necessary for C–C + pairing (see diagram), whereas formation of the i‐motif does not depend on the ribosyl–phosphodiester backbone.