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Covalent DNA–Streptavidin Conjugates as Building Blocks for Novel Biometallic Nanostructures
Author(s) -
Niemeyer Christof M.,
Bürger Wolfgang,
Peplies Jörg
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980904)37:16<2265::aid-anie2265>3.0.co;2-f
Subject(s) - streptavidin , oligonucleotide , conjugate , dna origami , supramolecular chemistry , nanostructure , dna , covalent bond , chemistry , nanocrystalline material , nanotechnology , self assembly , materials science , combinatorial chemistry , crystallography , biochemistry , biotin , organic chemistry , mathematical analysis , mathematics , crystal structure
Supramolecular aggregates of DNA, RNA, streptavidin, immunoglobulin, and nanocrystalline metal clusters can be generated by self‐assembly on the basis of oligonucleotide hybridization (shown schematically). Following selective immunosorption on surface‐immobilized antigen, the biometallic hybrid is detectable by electron microscopy.