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Rhodium‐Catalyzed Intermolecular [4+2] Cycloaddition of Unactivated Substrates
Author(s) -
Murakami Masahiro,
Ubukata Minoru,
Itami Kenichiro,
Ito Yoshihiko
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980904)37:16<2248::aid-anie2248>3.0.co;2-1
Subject(s) - rhodium , cycloaddition , intermolecular force , catalysis , chemistry , combinatorial chemistry , organic chemistry , molecule
No electron‐withdrawing or electron‐releasing substituents are necessary for the substrates in the rhodium‐catalyzed [4+2] cycloaddition reaction between a vinylallene and an ordinary alkyne under mild conditions [Eq. (1)]. The use of the strongly electron‐accepting P[OCH(CF 3 ) 2 ] 3 ligand affords the optimal rhodium catalyst. cod = 1,5‐cyclooctadiene.