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Total Synthesis of Chatancin
Author(s) -
Aigner Josef,
Gössinger Edda,
Kählig Hanspeter,
Menz Georg,
Pflugseder Karin
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980904)37:16<2226::aid-anie2226>3.0.co;2-h
Subject(s) - total synthesis , stereochemistry , diterpene , coral , antagonist , chemistry , biology , biochemistry , ecology , receptor
As an antagonist of the platelet activating factor , chatancin ( 1 ), which is isolated from a soft coral, is of potential therapeutic use. The first total synthesis [Eq. (1)] of this structurally unusual diterpene in racemic form is described along with the formal total syntheses of natural (+)‐chatancin as well as unnatural (−)‐chatancin.