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A Strong Positive Allosteric Effect in the Molecular Recognition of Dicarboxylic Acids by a Cerium( IV ) Bis[tetrakis(4‐pyridyl)porphyrinate] Double Decker
Author(s) -
Takeuchi Masayuki,
Imada Tomoyuki,
Shinkai Seiji
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980817)37:15<2096::aid-anie2096>3.0.co;2-b
Subject(s) - allosteric regulation , molecule , porphyrin , chemistry , cerium , gibbs free energy , stereochemistry , binding energy , dicarboxylic acid , crystallography , inorganic chemistry , photochemistry , receptor , polymer chemistry , physics , thermodynamics , organic chemistry , atomic physics , biochemistry
With increasing number of bound dicarboxylic acid molecules , the binding of further molecules by the title compound becomes more favorable (a 1:4 complex is depicted schematically on the right). The association constant for binding of the first guest molecule is small, since the increase in Gibbs free energy due to binding is outweighed by the energy loss asssociated with the suppression of rotation of the porphyrin rings. Once rotation has been suppressed, further guest molecules can be more effectively bound (positive allosteric effect).