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Synthesis, Structure, and Reactivity of a Palladium Hydrazonato Complex: A New Type of Reductive Elimination Reaction To Form C−N Bonds and Catalytic Arylation of Benzophenone Hydrazone
Author(s) -
Hartwig John F.
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980817)37:15<2090::aid-anie2090>3.0.co;2-a
Subject(s) - chemistry , benzophenone , aryl , hydrazone , palladium , alkyl , catalysis , reactivity (psychology) , medicinal chemistry , reductive elimination , halide , chelation , combinatorial chemistry , organic chemistry , medicine , alternative medicine , pathology
A rare, structurally characterized μ 1 , η 1 ‐hydrazonato complex is a probable intermediate in the Pd‐catalyzed N‐arylation of hydrazones. Starting from aryl halides the reaction proceeds efficiently and under mild conditions with chelating phosphane ligands (L 2 ); even Cs 2 CO 3 can be used as the base [Eq. (a)]. R=alkyl, aryl, MeCO, MeO; X=Br, I.