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Stereoselection at the Steady State: The Design of New Asymmetric Reactions
Author(s) -
Wirth Thomas
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980817)37:15<2069::aid-anie2069>3.0.co;2-#
Subject(s) - chemistry , computer science
Not a new principle , but a shrewd analysis of stereoconvergent reactions is leading to new and highly efficient asymmetric reactions. A prochiral compound can be converted through a clever combination of competing reactions, one of which must be stereoselective, into a sole chiral product (shown above). The strategy is reviewed by using a radical cyclization reaction as an example.