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C‐Terminal Peptide Amidation Catalyzed by Orange Flavedo Peptide Amidase
Author(s) -
Čeřovský Václav,
Kula MariaRegina
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980803)37:13/14<1885::aid-anie1885>3.0.co;2-c
Subject(s) - amidase , chemistry , peptide , amide , hydrolysis , residue (chemistry) , stereochemistry , peptide bond , organic chemistry , biochemistry
The reverse reaction of amide hydrolysis can be achieved with the peptide amidase derived from oranges [Eq (1); Z=benzyloxycarbonyl]. The C‐terminal carboxy group of the peptide is directly converted into an amide group by condensation with an ammonium salt. The amidation of peptides is of major interest since the biological activity of proteohormones and peptides is strongly influenced by the presence of a C‐terminal amide group.