Premium
A Stereospecific Geminal Alkylation Scheme En Route To CP‐225, 917 and CP‐263,114
Author(s) -
Kwon Ohyun,
Su DaiShi,
Meng Dongfang,
Deng Wei,
D'Amico Derin C.,
Danishefsky Samuel J.
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980803)37:13/14<1880::aid-anie1880>3.0.co;2-5
Subject(s) - geminal , stereospecificity , moiety , alkylation , maleic anhydride , chemistry , ylide , stereochemistry , medicinal chemistry , organic chemistry , catalysis , polymer , copolymer
The quaternary center at C7 of a precursor to the title compounds could be introduced by stereospecific addition of the Trost ylide to 1 . This along with a photooxidation that provides the required maleic anhydride moiety are two important steps in the total synthesis of the two compounds.