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Stereocontrolled Synthesis of the Everninomicin A 1 B(A)C Ring Framework
Author(s) -
Nicolaou K. C.,
Rodríguez Rosa M.,
Mitchell Helen J.,
van Delft Floris L.
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980803)37:13/14<1874::aid-anie1874>3.0.co;2-k
Subject(s) - ring (chemistry) , stereochemistry , chemistry , computer science , organic chemistry
A strategy based on a ring‐closing olefin metathesis was used to convert divinylmethanol into 1 , which served as a common precursor to activated derivatives 2 and 3 . These in turn serve as precursors to the C and B carbohydrate units of the A 1 B ( A ) C ring fragment 4 of everninomicin 13,384‐1.