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Highly Enantioselective Complex‐Catalyzed Reduction of Ketones— Now with Purely Aliphatic Derivatives Too
Author(s) -
Fehring Volker,
Selke Rüdiger
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980803)37:13/14<1827::aid-anie1827>3.0.co;2-c
Subject(s) - enantioselective synthesis , chemistry , catalysis , combinatorial chemistry , reduction (mathematics) , organic chemistry , geometry , mathematics
A breakthrough for the rhodium‐catalyzed asymmetric, homogeneous hydrogenation of unfunctionalized ketones was recently achieved by Zhang et al. with the synthesis and use of ligands 1 , named PennPhos, which combine high basisity and optimal spatial requirements with sufficient substituent flexibility.