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Isolation, Chemistry, and Biochemistry of Ptaquiloside, a Bracken Carcinogen
Author(s) -
Yamada Kiyoyuki,
Ojika Makoto,
Kigoshi Hideo
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980803)37:13/14<1818::aid-anie1818>3.0.co;2-8
Subject(s) - bracken , carcinogen , chemistry , isolation (microbiology) , dna , biochemistry , guanine , biology , botany , bioinformatics , fern , nucleotide , gene
A toxic and yet edible plant , bracken shows a carcinogenicity that has been a long‐standing problem. This review provides an account of the isolation, structure, and reactivity of ptaquiloside ( 1 ), a bracken carcinogen. The elimination of glucose from 1 results in the formation of an ultimate carcinogen that alkylates the adenine and guanine residues of DNA and even cleaves DNA.