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Methoxide Coordination at the Pocket of [Cu II Tp Cum, Me] and a Simple Model for the Cu Center of Galactose Oxidase
Author(s) -
Ruf Michael,
Pierpont Cortlandt G.
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980703)37:12<1736::aid-anie1736>3.0.co;2-v
Subject(s) - galactose oxidase , methoxide , galactose , chemistry , tyrosine , oxidase test , copper , stereochemistry , residue (chemistry) , biochemistry , enzyme , organic chemistry , catalysis
An unusually negative oxidation potential is found for the tyrosine residue in the center of fungal galactose oxidase. The complex [Cu(Tp Cum,Me ){O(MeS)C 6 H 4 }] (see picture on the right; Tp Cum,Me =hydrotris(pyrazolyl)borate) offers insight into the mode of (cysteinyl‐tyrosine) coordination to the copper center, and the reason for the low oxidation potential.