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Highly Enantioselective One‐Pot Synthesis of Chiral Tri‐ and Tetrasubstituted Ferrocenes from 1,1′‐Ferrocenedicarbaldehyde
Author(s) -
Iftime Gabriel,
Daran JeanClaude,
Manoury Eric,
Balavoine Gilbert G. A.
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980703)37:12<1698::aid-anie1698>3.0.co;2-d
Subject(s) - enantioselective synthesis , ferrocene , chirality (physics) , planar chirality , stereochemistry , chemistry , combinatorial chemistry , catalysis , organic chemistry , chiral symmetry , physics , electrode , quantum mechanics , nambu–jona lasinio model , electrochemistry , quark
Exclusively planar chirality is exhibited by the ferrocenes obtained in a highly enantioselective synthesis in which a chiral aminoamide acts as a temporary protecting/directing group. This method was used to obtain an enantiomerically pure tetrasubstituted ferrocene, which was transformed into the first C 2 ‐symmetric disubstituted ferrocenophane [Eq. (1)].