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Structure–Reactivity Relationship in the Reaction of Highly Reactive Zinc with Alkyl Bromides
Author(s) -
Guijarro Albert,
Rieke Reuben D.
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980703)37:12<1679::aid-anie1679>3.0.co;2-b
Subject(s) - zinc , moiety , chemistry , reactivity (psychology) , alkyl , magnesium , lithium (medication) , inorganic chemistry , organic chemistry , polymer chemistry , medicine , alternative medicine , pathology , endocrinology
Zinc is different! Unlike with magnesium or lithium, the reactions of organic bromides with highly reactive zinc (Zn*) show sensitivity for the structure of the organic moiety. Selective insertions of Zn into tertiary C–Br bonds can be achieved [Eq. (a)]. Competitive kinetic techniques were used to quantify these findings.