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The First Specific Ti IV –Protein Complex: Potential Relevance to Anticancer Activity of Titanocenes
Author(s) -
Sun Hongzhe,
Li Hongyan,
Weir Richard A.,
Sadler Peter J.
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980619)37:11<1577::aid-anie1577>3.0.co;2-m
Subject(s) - transferrin , titanium , chemistry , mechanism of action , nuclear magnetic resonance spectroscopy , pharmacology , combinatorial chemistry , stereochemistry , biochemistry , medicine , organic chemistry , in vitro
The transfer of titanium ions from titanium citrate and titanocene dichloride to the blood plasma protein transferrin was proven unequivocally by UV/Vis and NMR spectroscopy. The results may provide insight intoan important step in the mechanism of action of titanium anticancer drugs.