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Solid‐Phase Synthesis of Oligosaccharides: Construction of a Dodecasaccharide
Author(s) -
Nicolaou K. C.,
Watanabe Nobuhide,
Li Jim,
Pastor Joaquín,
Winssinger Nicolas
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980619)37:11<1559::aid-anie1559>3.0.co;2-e
Subject(s) - linker , solid phase synthesis , phase (matter) , chemistry , combinatorial chemistry , polymer chemistry , materials science , organic chemistry , computer science , biochemistry , peptide , operating system
Complicated oligosaccharides such as dodecasaccharide 1 can be constructed by a new solid‐phase strategy. The attachment to the polymeric support (gray sphere) is through a photolabile linker (structure I ), and thioglycosides serve as carbohydrate donors. Bn=benzyl, Bz=benzoyl.