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A Lysoganglioside/Poly‐ L ‐glutamic Acid Conjugate as a Picomolar Inhibitor of Influenza Hemagglutinin
Author(s) -
Kamitakahara Hiroshi,
Suzuki Takashi,
Nishigori Noriko,
Suzuki Yasuo,
Kanie Osamu,
Wong ChiHuey
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980619)37:11<1524::aid-anie1524>3.0.co;2-d
Subject(s) - polyglutamic acid , hemagglutinin (influenza) , conjugate , chemistry , epitope , in vitro , monoclonal antibody , virus , amphiphile , virology , influenza a virus , biochemistry , antibody , polymer , biology , copolymer , organic chemistry , immunology , mathematical analysis , mathematics
Based on the principle of a multivalent interaction, the amphiphilic polymer 1 , present in solution as an aggregate (see below right), is able to inhibit infection with the influenza virus. After recognition of a specific sialyllactose epitope through hemaglutinin (HA) on the virus surface, the sphingosine residues and the fluorescent tag form a stable complex with HA through hydrophobic interactions. Polymer 1 shows in vitro inhibitory activity 10 6 ‐fold greater than that of sialyllactose. PGA=polyglutamic acid.