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3,5′‐Anhydrosynadenol: A Polycyclic Anhydronucleoside Analogue
Author(s) -
Qiu YaoLing,
Zemlicka Jiri
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980605)37:10<1440::aid-anie1440>3.0.co;2-a
Subject(s) - chemistry , phosphorylation , nucleoside , nucleoside analogue , stereochemistry , biochemistry
Cyclization instead of O‐phosphorylation is the result of the reaction of the antiviral nucleoside anologue 1 with highly reactive phosphorylating agents. The formation of the novel polycyclic compound 2 shows that 1 has the Z configuration, which is important for the antiviral activity of 1 and related compounds.