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New Polyol Syntheses
Author(s) -
Schneider Christoph
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980605)37:10<1375::aid-anie1375>3.0.co;2-h
Subject(s) - polyol , cyanohydrin , polyene , stereoselectivity , alkylation , diol , chemistry , organic chemistry , catalysis , polyurethane
1,3,5,…‐Polyol structures are characteristic components of polyene macrolide antibiotics such as filipin III ( 1 ). Iterative stereoselective alkylation of lithiated cyanohydrin acetonides and subsequent reductive decyanation is one possibility for the stepwise synthesis of this class of natural products characterized by a polyol framework of 1,3‐diol units.