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Strategy‐Level Separations in Organic Synthesis: From Planning to Practice
Author(s) -
Curran Dennis P.
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980518)37:9<1174::aid-anie1174>3.0.co;2-p
Subject(s) - separation (statistics) , organic synthesis , computer science , biochemical engineering , process engineering , combinatorial chemistry , chemistry , engineering , organic chemistry , catalysis , machine learning
A dirty word in synthesis: separation! The normally unavoidable separation at the end of each reaction finds no friends among synthetic chemists and is often regarded as a technical procedure. However, the need to quickly and cheaply produce pure products is driving the development of new separation and purification techniques. Astonishingly, the modern concepts and techniques for coupling synthesis and separation are rooted in workup procedures that are as old as the art of synthesis itself.