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Amine Additives Greatly Expand the Scope of Asymmetric Hydrosilylation of Imines
Author(s) -
Verdaguer Xavier,
Lange Udo E. W.,
Buchwald Stephen L.
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980504)37:8<1103::aid-anie1103>3.0.co;2-m
Subject(s) - amine gas treating , hydrosilylation , scope (computer science) , chemistry , catalysis , primary (astronomy) , organic chemistry , polymer chemistry , combinatorial chemistry , computer science , physics , astronomy , programming language
Slow addition of a primary amine to the reaction mixture greatly increases the scope of the titanium‐catalyzed asymmetric reduction of imines 1 . An important added feature of this method is that chiral secondary amines 2 can be obtained in much higher optical purity (up to 99 % ee ) than would be predicted from the E : Z ratios of the starting imines 1 .