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Highly Enantioselective Hydrogenation of Simple Ketones Catalyzed by a Rh–PennPhos Complex
Author(s) -
Jiang Qiongzhong,
Jiang Yutong,
Xiao Dengming,
Cao Ping,
Zhang Xumu
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980504)37:8<1100::aid-anie1100>3.0.co;2-3
Subject(s) - enantioselective synthesis , catalysis , simple (philosophy) , noyori asymmetric hydrogenation , chemistry , organic chemistry , combinatorial chemistry , philosophy , epistemology
Abstract Even alkyl methyl ketones undergo asymmetric hydrogenation with high enantioselectivity when a rhodium complex of the conformationally rigid chiral ligand 1 (Me‐PennPhos; R=CH 3 ) is used as the catalyst. Basic additives such as 2,6‐lutidine contribute to the achievement of high enantiomeric excesses.