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Direct Observation of Radical Intermediates While Investigating the Redox Behavior of Thiamin Coenzyme Models
Author(s) -
Nakanishi Ikuo,
Itoh Shinobu,
Suenobu Tomoyoshi,
Fukuzumi Shunichi
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980420)37:7<992::aid-anie992>3.0.co;2-p
Subject(s) - redox , chemistry , electron paramagnetic resonance , radical , cofactor , cyclic voltammetry , photochemistry , aldehyde , active site , electrochemistry , inorganic chemistry , enzyme , organic chemistry , catalysis , nuclear magnetic resonance , physics , electrode
The redox behavior of “active aldehydes” 1 − derived from 3‐benzylthiazolium salts and simple aldehydes in the presence of a base has been examined with low‐temperature cyclic voltammetry and EPR spectroscopy. The highly negative oxidation potentials of 1 − and the spin distribution of the intermediate radicals 1 . indicate that the active aldehyde can act as an efficient electron mediator in thiamin‐dependent enzymatic redox systems.