Premium
Total Synthesis of Terprenin, a Highly Potent and Novel Immunoglobulin E Antibody Suppressant
Author(s) -
Kawada Kenji,
Arimura Akinori,
Tsuri Tatsuo,
Fuji Masahiro,
Komurasaki Tadafumi,
Yonezawa Shuji,
Kugimiya Akira,
Haga Nobuhiro,
Mitsumori Susumu,
Inagaki Masanao,
Nakatani Takuji,
Tamura Yoshinori,
Takechi Shozo,
Taishi Teruhiko,
Kishino Junji,
Ohtani Mitsuaki
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980420)37:7<973::aid-anie973>3.0.co;2-t
Subject(s) - regioselectivity , chemistry , linkage (software) , total synthesis , antibody , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , immunology , catalysis , medicine , gene
Regioselective halogenations and Suzuki reactions ensure proper linkage of the aromatic rings in two total syntheses of terprenin ( 1 ). Both routes make it possible to prepare 1 efficiently and in large quantity.