Abstract Exceptional neurotoxicity is associated with ciguatoxin. The ciguatoxin mimic 1 , which contains the F–M framework of the natural product, has been prepared through a convergent synthesis. The two key steps were a Lewis acid mediated intramolecular reaction of a γ ‐alkoxyallylsilane with an acetal group and an SmI 2 ‐mediated intramolecular Reformatsky reaction that permitted construction of the annelated hexahydrooxonin ring system.