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Rate Acceleration in Nucleophilic Alkylation of Carbonyl Compounds with a New Template Containing Two Metallic Centers
Author(s) -
Ooi Takashi,
Takahashi Makoto,
Maruoka Keiji
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980403)37:6<835::aid-anie835>3.0.co;2-z
Subject(s) - alkylation , alkyl , nucleophile , chemistry , carbon atom , aluminium , metal , atom (system on chip) , transition metal , nucleophilic addition , carbon fibers , acceleration , organic chemistry , materials science , catalysis , physics , classical mechanics , computer science , embedded system , composite number , composite material
Two aluminum centers aligned in the same direction capture carbonyl groups in such a way that efficient alkyl transfer becomes possible from aluminum to the carbon atom. This occurs via a favorable cyclic six‐membered transition state ( 1 ). Carbonyl compounds can now be alkylated with otherwise less reactive alkylmetal species.