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Heck Reactions without Salt Formation: Aromatic Carboxylic Anhydrides as Arylating Agents
Author(s) -
Stephan Massoud S.,
Teunissen Antonius J. J. M.,
Verzijl Gerard K. M.,
de Vries Johannes G.
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980316)37:5<662::aid-anie662>3.0.co;2-0
Subject(s) - chemistry , catalysis , halide , halogen , heck reaction , organic chemistry , salt (chemistry) , chloride , combinatorial chemistry , palladium , alkyl
Environmentally benign and economical production of arylated olefins can be achieved by a new variant of the Heck reaction in which no halogen salts are formed. The trick is the use of aromatic carboxylic anhydrides 1 as arylating agents. With halide‐activated palladium chloride as catalyst, which requires no phosphane ligands, the olefins 2 can be prepared according to Equation (a) in good yields.